Nathan Smith talks about the CSS framework that he created called Formalize, which allows designers to have more control over styling form elements. He sees it as a reset for forms, and created it because he was frustrated about the gap between the original design intention and the final implementation. He also talks a bit about the 960 grid system, which he also created, and how he got involved with the Drupal community. He also talks a bit about mobile design, and how the larger variance of screen sizes has created different design demands and implementations like the 960 grid on jQuery mobile system.
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